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This reactive epoxide intermediate might react with amino acid residues of a CYP enzyme to type drug-CYP (drug-protein) adducts (Scheme 6, pathway C). The formation with the drug-CYP adducts might or might not show a time-dependent inactivation in the catalytic action of the CYP enzyme, depending upon the covalent binding on the reactive intermedia
A review executed on animals for variety 2 diabetes confirmed the intake of synthetic sweeteners can impact diabetic issues-relevant parameters and troubles affiliated with diabetes [58]. The final results corroborate the hypothesis the intake of artificial non-nutritive sweeteners is associated with weight problems or weight problems-like outcomes